Investigating Amyloid Plaques in Alzheimer's Disease Using IR and Raman Microscopy
- The Infrared Microscope allows for full tissue mapping at discrete frequencies
- The Raman Microscope offers structural data complimentary to infrared, giving us a comprehensive insight into plaque chemistry
- IR and Raman microscopy are complimentary methods that can be used to characterize and understand chemical signatures of protein aggregates and other biomolecules in Alzheimer's Disease.
- This combination of techniques allows us to obtain spatial images as well as chemical information of both small and large sample areas with enhanced resolution. Our goal is to understand how chemical composition of amyloid aggregates relates to disease pathology.